Anneke Haagen was beginning to feel that maybe her marriage to police lieutenant Karl Genesko would never take place, but they were finally able to tie the knot in The Wedding Game and are now in San Francisco, enjoying their honeymoon.

The trip starts out well - they get in a little sight-seeing and even catch a 49ers game, which Karl, a former football player, loves. Then they receive an invitation from Richard Killian, Anneke's friend, to come and watch the University of Michigan game at his sports bar, Maize and Blue, on Saturday. Anneke gladly accepts the invitation, because what could be better than getting free food and watching the game surrounded by Michigan alumni?

But when Anneke and Karl arrive, they discover that a number of things would have been better than going to Maize and Blue. As Anneke tries to watch the game, everyone around her keeps talking about food. Phrases such as "Big Nate - now, that's the kind of barbecue that ..." and "They do the best tampoi rice I've ever tasted" dominate the conversation. To make matters even worse, a Michigan graduate student, Lindsay Summers, is questioning everyone about what triggers their urges to overeat, which doesn't make her very popular. But is that reason enough to kill her?

Anneke and Karl soon find themselves dragged into the investigation to help their friend Richard, who has become the prime suspect. As they search for answers amid a shish kebab of food activists with a dozen different agendas, Zoe Kaplan, Anneke's friend in Ann Arbor, makes a startling discovery that turns the investigation upside down and almost turns Zoe into another victim.