Martin Tyler is a 44-year-old janitor whose life has come to a sputtering halt; he has no friends, no family, and no promise of better days ahead. In the grip of blackest depression, he attempts to take his own life, only to find himself waking up in a local mental health facility where he has been placed for observation.

But something more has happened to Martin than just a failed suicide attempt; certain doors of perception have been unlocked in his mind, allowing him to see fantastic creatures that lurk outside on the streets of Cedar Hill - creatures only he can perceive.

Over the next 48 hours, Martin will discover what these creatures are, who controls them, and why he must enter The Midnight Museum, a place with no doors or windows, but many entrances and exits; a place just outside the perception of everyday life; a place where Martin will discover how and why he inadvertently holds the fate of the world in his hands.