Jeannie Sterling, host of a late-night NYC talk show, vents with her listeners about everyday injustices, from rude cell phone users and poor gym etiquette to bad drivers and negligent pet owners -- the many aggravations of modern urban life. An idealistic California girl raised by two free-spirited parents, Jeannie believes in a life of value through activism. She's passionate about making a difference, about making the world a better place, one annoying person at a time.

For as long as she can remember, success in her career has been more than enough. But after all these years of being single, Jeannie realizes that some of the pieces of her perfect puzzle aren't fitting quite right. The people she thought she knew best all harbor secrets, secrets Jeannie isn't prepared for, secrets that can't be digested, processed, and solved in the neat three-hour window of her show. Her best friend, Luce, is growing distant and distracted; her wayward father unexpectedly moves in; and an ambiguous relationship with her college crush ignites.

When the radio station is bought by the maverick mogul Nicholas Moss, Jeannie's career, her one safe haven, also descends into chaos. She is pushed to increase ratings and goes too far, risking the loss of everything and everyone important to her.