After her Aunt Teza's test results turn out to be inconclusive, Dot Cooper resolves to raise money for a new mammogram machine, through the creation and auction of a magnificent, king-sized quilt to be sewn by the women of Jefferson City.

Dot's efforts quickly draw the support of disparate members of the community, including newcomer Beth Donnelly, married to a local pastor, Elaine Giovanni, the stylish wife of a local surgeon; and an ailing Aunt Teza. But as the four different generations work the squares of the quilt, they are also confronted with ragged pieces of their own lives.

Though the women could not be more different on the surface, they hold in common quiet suffering triggered by painful circumstances: the death of children, the abandonment of husbands, the loneliness of depression. Yet their struggles will bring them closer together than they ever could have anticipated, and their lives will be dramatically changed, as together they experience the curative powers of The Healing Quilt.