In the third installment of The Big Empty, the teens are on the run after making the shocking discovery that the leader of Novo Mundum, the secret community hidden in the middle of the evacuated Big Empty, is developing a new, even more dangerous virus.

The group faces a challenging trek through the forbidden zone as they search for someone they can trust. In a journey that will test their survival skills like nothing they've experienced so far, the teens' relationships are pushed to the breaking point, with one couple ripped apart for good. An unexpected reunion with someone from their past will prove to be a turning point-but will this familiar face bring salvation or ruin?