Months after foiling an attack on a commercial jetliner, Doctors Without Borders physician Jonathan Ransom is working under an assumed name in a remote corner of Africa, while his newly revealed spy wife, Emma, desperate to escape the wrath of Division, the secret American intelligence agency she betrayed, has vanished into the netherworld of international espionage. Both look forward to sharing a stolen weekend in London - until an ambush on a convoy of limousines turns their romantic rendezvous into a terrorist bloodbath. In the confusion, Emma disappears.

Jonathan is first hailed as a hero for his valiant actions during the violence, but when surveillance footage makes it unclear whether he was trying to stop the terrorists, or aid them, he quickly turns from savior to suspect. Once more on the run, Jonathan realizes that the only way to clear his name is to locate Emma, but finding her may prove that all along he's been a pawn in a game far beyond his imagining....