In A Sicilian Romance (1790) Radcliffe began to forge the unique mixture of the psychology of terror and poetic description that would make her the great exemplar of the Gothic novel, and the idol of the Romantics.

This early novel explores the cavernous landscapes and labyrinthine passages of Sicily's castles and covents to reveal the shameful secrets of its all-powerful aristocracy. Julia and Emilia Mazzini live secluded in an ancient mansion near the Straits of Messina. After their father's return to the island a neglected part of the house is haunted by a series of mysterious sights and sounds. The origin of these hauntings is only discovered after a series of breathless pursuits through dreamlikepastoral landscapes. When revelation finally comes, it forces the heroines to challenge the united forces of religious and patriarchal authority.