On the sultry streets of New Orleans, Captain Scott Boulder and Leah Maguire are about to begin a deadly mission. The traumatized, genetically altered subjects of a Department of Defense experiment gone wrong have escaped, among them Rachel Ackart, a beautiful, seductive, and powerful woman-who is now under the dangerous influence of Andre Espinoza de Madrid, a vampire of incomparable evil and power.

While Predator drones circle above New Orleans, and the sound of Black Hawk helicopters rends the air, Scott and Leah must fight their growing attraction to each other as they pursue their quarry amid the haunted and the damned. But Rachel is one step ahead of them. Andre's vampire agent will soon unleash the greatest terror of all.