From Publishers Weekly
The difficult choices a family must make when a child is diagnosed with a serious disease are explored with pathos and understanding in this 11th novel by Picoult (Second Glance, etc.). The author, who has taken on such controversial subjects as euthanasia (Mercy), teen suicide (The Pact) and sterilization laws (Second Glance), turns her gaze on genetic planning, the prospect of creating babies for health purposes and the ethical and moral fallout that results. Kate Fitzgerald has a rare form of leukemia. Her sister, Anna, was conceived to provide a donor match for procedures that become increasingly invasive. At 13, Anna hires a lawyer so that she can sue her parents for the right to make her own decisions about how her body is used when a kidney transplant is planned. Meanwhile, Jesse, the neglected oldest child of the family, is out setting fires, which his firefighter father, Brian, inevitably puts out. Picoult uses multiple viewpoints to reveal each character's intentions and observations, but she doesn't manage her transitions as gracefully as usual; a series of flashbacks are abrupt. Nor is Sara, the children's mother, as well developed and three-dimensional as previous Picoult protagonists. Her devotion to Kate is understandable, but her complete lack of sympathy for Anna's predicament until the trial does not ring true, nor can we buy that Sara would dust off her law degree and represent herself in such a complicated case. Nevertheless, Picoult ably explores a complex subject with bravado and clarity, and comes up with a heart-wrenching, unexpected plot twist at the book's conclusion.
Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.

From Booklist
*Starred Review* Expect to be kept up all night by Picoult's latest novel, but it's much more than a page-turner; it's a fascinating character study framed by a complex, gripping story. Thirteen-year-old Anna Fitzgerald walks into the office of lawyer Campbell Alexander and announces she wants to sue her parents for the rights to her own body. Anna was conceived after her older sister, Kate, developed a rare form of leukemia at the age of two, and has donated bone marrow and blood to her sister. Now she has been asked to donate a kidney, and she intends to refuse. Campbell is a jaded young man who nevertheless decides to take her case pro bono. Anna's parents are shocked when they learn of her lawsuit, and her mother, a former civil defense attorney, decides to represent them. Anna refuses to budge on her position despite the fact that she clearly loves her sister and longs for her family's happiness. As the gripping court case builds, the story takes a shocking turn. Told in alternating perspectives by the engaging, fascinating cast of characters, Picoult's novel grabs the reader from the first page and never lets go. This is a beautiful, heartbreaking, controversial, and honest book. Kristine Huntley
Copyright © American Library Association. All rights reserved

Book Description
New York Times bestselling author Jodi Picoult is widely acclaimed for her keen insights into the hearts and minds of real people. Now she tells the emotionally riveting story of a family torn apart by conflicting needs and a passionate love that triumphs over human weakness.

Anna is not sick, but she might as well be. By age thirteen, she has undergone countless surgeries, transfusions, and shots so that her older sister, Kate, can somehow fight the leukemia that has plagued her since childhood. The product of preimplantation genetic diagnosis, Anna was conceived as a bone marrow match for Kate -- a life and a role that she has never challenged...until now. Like most teenagers, Anna is beginning to question who she truly is. But unlike most teenagers, she has always been defined in terms of her sister -- and so Anna makes a decision that for most would be unthinkable, a decision that will tear her family apart and have perhaps fatal consequences for the sister she loves.

My Sister's Keeper examines what it means to be a good parent, a good sister, a good person. Is it morally correct to do whatever it takes to save a child's life, even if that means infringing upon the rights of another? Is it worth trying to discover who you really are, if that quest makes you like yourself less? Should you follow your own heart, or let others lead you? Once again, in My Sister's Keeper, Jodi Picoult tackles a controversial real-life subject with grace, wisdom, and sensitivity.