In a sprawling villa on the outskirts of Rome, the internationally revered pediatric oncologist Leo Pontecorvo and his family - wife Rachel and their two amiable children - have gathered for dinner. The scene is perfect in every way, until, that is, a horrifying accusation airs on the evening news concerning Leo Pontecorvo himself. From this point on, nothing will ever be the same. A spotlight is turned on Leo that reveals the mistakes, regrets, and contradictions of a lifetime. Every detail of his private and professional life is about to come under scrutiny, to be debated by both friends and foes, by ravenous reporters and punctilious prosecutors. But Leo could bear all this if it weren't for the suspicious gazes of his wife and children. Surely they, of all people, believe in his innocence!