More than four hundred years after the events of Shakespeare's The Tempest, the sorcerer Prospero, his daughter Miranda, and his other children have attained everlasting life. Miranda is the head of her family's business, Prospero Inc., which secretly has used its magic for good around the world. One day, Miranda receives a warning from her father: "Beware of the Three Shadowed Ones." When Miranda goes to her father for an explanation, he is nowhere to be found.

Miranda sets out to find her father and reunite with her estranged siblings, each of which holds a staff of power and secrets about Miranda's sometimes-foggy past. Her journey through the past, present and future will take her to Venice, Chicago, the Caribbean, Washington, D.C., and the North Pole. To aid her, Miranda brings along Mab, an aerie being who acts like a hard-boiled detective, and Mephistopheles, her mentally-unbalanced brother. Together, they must ward off the Shadowed Ones and other ancient demons who want Prospero's power for their own.