A hundred years ago, Dr. Evan McGrath realized his dream of establishing a hospital in the Pacific Northwest, a hospital that would never turn away a patient in need. But the personal cost was steep: Evan lost the love of his life while making a powerful enemy of the hospital's financier, Marshall Alfredson.

Today, the Alfredson Medical Center is internationally renowned for its care. The two founding families remain faithful to Evan's vision, but their history is clouded by forbidden love, conflict, and betrayal. Crisis is besieging the Alfredson. A decision by Dr. Tyler McGrath, a child cancer specialist, leaves a young patient's family shattered. Dr. Jill Laidlaw, Tyler's wife, is a researcher poised to offer fresh hope to multiple sclerosis victims - including a former presidential frontrunner - until rumors of research fraud endanger her career. And in the face of temptation and career demands, Tyler and Jill are drifting apart.

Devastating family secrets, doomed relationships, and present-day medical disasters threaten not only the Alfredsons and McGraths but the legendary hospital itself.