Cadence reunites us with Andrew Carmichael, an inner city physician, and his partner in practice, Bethany Cole, one of the first female physicians in America, who share a desire to serve the poor with their healing skills and with love. As the story continues, they discover that they share more than a professional passion--they share a love for each other.

Set in late nineteenth century New York City and the surrounding Hudson River Valley, and incorporating the beginnings of American gospel music, Cadence continues the saga of the courageous immigrants who helped build our nation, the struggles they endured, and the music they created, lived and loved by.