In The Family Markowitz, Allegra Goodman writes with wit and compassion of three generations of Markowitzes making their way in America. At the center is Rose, the cantankerous matriarch, who longs for her earlier life in London and Vienna but is now forced into dependency on her sons Ed, an academic expert on terrorism (ahead of his time!), and Henry, an artistic expatriate with a taste for antiques and postmodern poetry. Also in the family circle are Sarah, Ed's wife, who teaches creative writing and longs for a more literary life, and Sarah and Ed's daughter Miriam, a medical student who causes great alarm in her largely assimilated family by rediscovering Judaism.

Through her sharp-eyed observations of weddings, hospital vigils, holiday dinners, and other rituals of family life, Goodman writes about the Markowitzes from the inside, bringing each character to life.