After making his presence known in Transmetropolitan: Back on the Streets, renegade columnist Spider Jerusalem targets three of society's most worshipped and warped pillars: politics, religion, and television. When Spider tries to shed light on the atrocities of these institutions, he finds himself fleeing a group of hitmen/kidnappers in possession of his ex-wife's frozen head, a distorted creature alleging to be his son, and a vicious talking police dog.