Harry is a man still mourning the loss of his beloved girlfriend, Imogen, who left him suddenly without a word. He's also the owner of a plump, poetry-loving Lab, Randolph. Like most Manhattan dogs, Randolph spends his days sifting through a world of scents, his owner's neuroses, and an overcrowded doggy run at the American Museum of Natural History. But now a bereft Harry has drifted into a circle of would-be occultists. Which might not be so bad if one of them wasn't also a murderer.

But which one? With 100,000 times the smelling power of a human being, Randolph can quickly detect the scents of guilt, anxiety, and avarice—and he has no lack of suspects, from a seductive con woman to an uncouth professor of the decorative arts. Now, to protect his hapless owner's life, Randolph might have to do the unthinkable—and start training Harry to catch a killer….