Deep in the Romanian countryside a child is born half mortal, half vampire. When the baby and her sibling are kidnapped, it sparks a search by their vampire parents who vow to return Arianne and her brother, Michael, to Von Tirgov castle as heirs to the vampire legacy. The twenty-eight-year search is about to end with their arrival in America.

Time is running out for Dr. Arianne Brasov as she struggles to reverse her family's curse through DNA manipulation. When the one person who can save her is brutally murdered, she realizes she could be forced to take her place as full vampire and fulfill destiny's call...