In 1975, twenty-five-year-old Rose MacGregor moves to St. Paul, Minnesota, with nothing but a few books, her cello, and a temporary professorship at a Midwestern college. The only woman in the music department, the other professors refer to her derisively as "the Girl Composer," but she believes that a brilliant career writing music lies ahead.

Passionately focused on her art, she also longs to find love, but her fierce independence always seems to get in the way of romantic relationships. Struggling with loneliness and ambition, she gets tangled up with a gay colleague, a self-made stonemason, a lesbian cellist, and the troubles of her wayward younger sister, before finally finding happiness.