From the bestselling author of The Plague Tales comes a spellbinding new novel that sweeps from medieval France to America in the year 2007-interweaving two gripping stories and two extraordinary eras....

In fourteenth-century France, pockets of plague still bring death to peasants and noblemen alike. Amid the fury and the chaos, Dr. Alejandro Canches searches for a safe haven, accompanied by his foster child, Kate-the illegitimate daughter of Edward Plantagenet. But both disease and human enemies pursue them, and their only hope for survival is a rebel leader... and medical secrets that lie hidden in an ancient manuscript.

Seven hundred years later, Dr. Janie Crowe is searching for the cure for a crippling disease in a world where genetic engineering has gone mad. A repressive government wants to stop her, unnamed benefactors want to help her, and time is running out to find answers linking two dark eras, two dedicated doctors, and one miraculous book....